Sophia Children's Hospital | Research

Research groups (18)

Atopic derma­titis & the Atopic­ syndrome

Atopic dermatitis is the commonest chronic skin disease in children. It is mild in about 70% of cases, moderate in 25% and severe in 5% severe AD.

Autism Spectrum Disorder

We disentangle the autism spectrum phenotype using various diagnostic approaches, relate the core problems to frequent other problems, and explore developmental courses.

GI-Genetics Hirschsprung disease (HSCR)

Which genetic factors determine the development of the gastrointestinal (GI) tract, and how do these genetic factors contribute to disease development?

Hearing loss in children

Although most apparent in later stages of life, it is probable that hearing acuity gradually declines with age and should therefore be studied at young ages as well.

Immune­dysregula­tion in atopic skin diseases

Atopic dermatitis and Netherton syndrome might be systemic diseases like primary immunodeficiencies (PIDs).

Laryngotracheal stenosis

Acquired pediatric laryngotracheal stenosis (LTS) is a rare but life-threatening disease which usually occurs after a prolonged period of intubation.

LungAnalysis Core Lab

LungAnalysis is an image analysis laboratory of the Erasmus Lung Imaging Group.

Lysosomal and Metabolic Diseases - Clinical Research

Lysosomal and metabolic diseases are rare genetic disorders caused by metabolic enzyme deficiency.

Macrophages in the healthy and diseased brain

Mutations in genes important for microglia, the brain’s macrophages, can predispose to brain diseases such as Alzheimer’s. The underlying mechanisms are largely unknown.

Molecular stem cell biology of lysosomal storage diseases

These diseases are rare genetic disorders caused by a deficiency of metabolic enzymes. Metabolic products accumulate throughout the body, affecting multiple organs and tissues.

Myopia (nearsightedness)

Our research groups investigates how a complex interplay between genetic and environmental factors leads to high myopia and how this can be prevented.

Pediatric Gastroenterology & Nutrition - Samsom lab

Which immune regulatory processes are essential to develop and maintain the intestinal immune system’s tolerance to dietary antigens and commensal bacteria?

Pediatric Infection and Immunity

Pneumonia is the number one cause of mortality in children. We aim to improve the diagnostics to prevent inappropriate antibiotics use.

Pediatric psychology Erasmus MC-Sophia

Pediatric psychology entails practice, targeting the psychology of illness and injury, and promoting health behaviors in children, adolescents, and families.

Rare Skin Diseases

Children may be affected by a wide range of rare skin diseases, the care and cure of which are little known.

Research in General Pediatric Emergency Care

Focus on research questions arising from the clinical care at the pediatric emergency department.


Stuttering is a developmental speech production disorder that starts in childhood at an early phase.

Vascular Anomaly Center

We perform clinical research on vascular anomalies such as hemangioma, kaposiform hemangioendothelioma and capillary, venous, and lymphatic malformations.